The reference site for Ipratropium

Ipratropium bromide, sold under the trade name Atrovent among others, is a medication which opens up the medium and large airways in the lungs.

WHAT IS Ipratropium?

Ipratropium is an anticholinergic drug administered by inhalation for the treatment of obstructive lung diseases such as asthma, chronic bronchitis, and emphysema. Ipratropium helps decrease coughing, wheezing, shortness of breath, and troubled breathing by increasing the flow of air into the lungs.

It is available under the trade names Alti-Ipratropium® (AltiMed), Apo-Ipravent® (Apotex), Atrovent Inhalation Aerosol® (Boehringer Ingelheim), Atrovent Inhalation Solution® (Boehringer Ingelheim), Atrovent Nasal Spray® (Boehringer Ingelheim), Gen-Ipratropium® (Genpharm), Novo-Ipramide® (Novopharm), Nu-Ipratropium® (Nu-Pharm), PMS-Ipratropuim® (Pharmascience).

 

Brand Name(s): Atrovent; Combivent (combined with Albuterol Sulfate)

CAS nº: 60205-81-4, 22254-24-6 (bromide)

(i pra troe’ pee um)

 

Product Info

The sections below will provide you with more specific information and guidelines related to ipratropium and its correct use. Please read them carefully.

FDA Information

Ipratropium oral inhalation was originally approved by the FDA in December 1986 and came off patent in August 1991. In July 1994, an FDA advisory committee voted to approve a combination product of ipratropium with albuterol.

In 1995, ipratropium nasal spray was approved for the treatment of rhinorrhea associated with the common cold or with allergic or nonallergic seasonal rhinitis.
Following this, in November 2004 the FDA approved Atrovent® HFA, a chlorofluorocarbon (CFC) free inhalation aerosol formulation.

Why is this medication prescribed?

Ipratropium is an anticholinergic drug administered by inhalation for the treatment of obstructive lung diseases such as asthma, chronic bronchitis, and emphysema.

Ipratropium helps decrease coughing, wheezing, shortness of breath, and troubled breathing by increasing the flow of air into the lungs.

It is available under the trade names Alti-Ipratropium® (AltiMed), Apo-Ipravent® (Apotex), Atrovent Inhalation Aerosol® (Boehringer Ingelheim), Atrovent Inhalation Solution® (Boehringer Ingelheim), Atrovent Nasal Spray® (Boehringer Ingelheim), Gen-Ipratropium® (Genpharm), Novo-Ipramide® (Novopharm), Nu-Ipratropium® (Nu-Pharm), PMS-Ipratropuim® (Pharmascience).

Other uses for this medicine

This medication may also be used in combination with other bronchodilators to treat acute, severe attacks of asthma in select patients.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Use ipratropium inhalation exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

To use the inhaler:

Shake the inhaler several times and uncap the mouthpiece.

Breathe out fully.

Put the mouthpiece of the inhaler or spacer into your mouth.

Be sure the mouthpiece is above the tongue and past the teeth. Alternatively, place the inhaler mouthpiece (not with spacer attached) several inches in front of your open mouth, if directed to do so by your doctor.

Take a deep, slow breath as you push down on the canister. Hold your breath for 10 seconds, then exhale slowly.

If you take more than one dose at a time, wait for at least 1 full minute, then repeat the procedure.

Keep your inhaler clean and dry. Keep the mouthpiece capped to avoid getting dirt inside it. Clean your inhaler once a day by removing the canister and immersing the mouthpiece in warm water. Allow the parts to dry, and then reassemble the inhaler. 

To use the solution for nebulization:

Measure the correct amount of medication with the dropper provided or select the prescribed number of ampules.

Transfer the liquid into the medication chamber of the nebulizer. If your medication has a dropper, do not allow the dropper to touch any surface including your hands or the chamber of the nebulizer.

Dilute the medication with normal saline if prescribed by your doctor. Attach the mouthpiece or face mask to the drug chamber. Then, attach the drug chamber to the compressor.

Sit upright, in a comfortable position, and put the mouthpiece into your mouth or put the face mask on, covering the nose and mouth.

Breathe slowly and evenly until all of the medicine has been inhaled (usually 5 to 15 minutes).

The treatment is complete when no more mist is formed by the nebulizer and the drug chamber is empty.

Clean the nebulizer after a treatment as directed by the manufacturer.

It is very important that you use the ipratropium inhaler properly, so that the medicine gets into the lungs.

Your doctor may want you to use a spacer with the inhaler. Talk to your doctor about proper inhaler use. It is important to use ipratropium inhalation regularly to get the most benefit.

Seek medical attention if you notice that you require more than your usual or more than the maximum amount of any asthma medication in a 24-hour period. An increased need for medication could be an early sign of a serious asthma attack.

Your doctor may want you to have lung function tests or other medical evaluations during treatment with ipratropuim inhalation to monitor progress and side effects.

What special precautions should I follow?

BEFORE TAKING IPRATROPIUM:

Tell your doctor if you have glaucoma, which may get worse if you use ipratropium, or an enlarged prostate or a bladder obstruction, which also may worsen if you use ipratropium.

Do not use ipratropium inhalation if you have a soya lecithin allergy (e.g., soybeans or peanuts).

You may not be able to use ipratropium inhalation, or you may require a lower dose or special monitoring during treatment, if you have either of the conditions listed above.

Ipratropium inhalation is in the FDA pregnancy category B. This means that it is unlikely to be harmful to an unborn baby. Do not, however, use ipratropium inhalation without first talking with your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether ipratropium passes into breast milk. Do not use ipratropium inhalation without first consulting this with your doctor if you are breast-feeding a baby.

Ipratropium inhalation is not approved for use by children younger than 12 years of age.

What should I do if I forget a dose?

Use the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and use the next one as directed.

It is strongly advised not to use a double dose of this medication.

What side effects can this medication cause?

Some common ipratropium side effects include:

feeling dizzy
tremor or feeling nervous or anxious
headache
cough or runny nose
upset stomach
leg cramps

Tell your doctor if any of these symptoms are severe or do not go away:

cough
dry mouth or throat irritation
nervousness
dizziness
headache
upset stomach
joint or muscle pain

If you experience any of the following symptoms, call your doctor immediately:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
a racing heart rate

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed. If you have any doubts, please talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

chest pain (angina)
high blood pressure
rapid heartbeat

Product Images

PICTURES OF IPRATROPIUM PILLS

Below you will find images and specific information on the principal types of ipratropium that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: ATROVENT
Strength(s): 0.02%
Imprint: Ipratropium Bromide
Manufacturer: DEY LABS.

Name: ATROVENT
Strength(s): 0.02%
Imprint: Ipratropium Bromide
Manufacturer: IVAX PHARMACEUTICALS

Name: IPRATROPIUM
Strength(s): 0.03%
Imprint: Ipratropium 0.03%
Manufacturer: APOTEX CORP.

Name: ATROVENT
Strength(s): 0.03%
Imprint: ATROVENT
Manufacturer: BOEHRINGER ING.

Name: IPRATROPIUM
Strength(s): 0.03%
Imprint: BAUSCH & LOMB
Manufacturer: BAUSCH & LOMB RX

Name: IPRATROPIUM
Strength(s): 0.03%
Imprint: IPRATROPIUM BROMIDE
Manufacturer: ROXANE LABS.

Name: ATROVENT
Strength(s): 0.06%
Imprint: ATROVENT
Manufacturer: BOEHRINGER ING.

Name: IPRATROPIUM
Strength(s): 0.06%
Imprint: IPRATROPIUM
Manufacturer: APOTEX CORP.

Name: IPRATROPIUM
Strength(s): 0.06%
Imprint: Ipratropium Bromide
Manufacturer: BAUSCH & LOMB RX

Name: IPRATROPIUM
Strength(s): 0.06%
Imprint: IPRATROPIUM BROMIDE
Manufacturer: ROXANE LABS.

Name: ATROVENT INHALER
Strength(s): 14 grams
Imprint: Atrovent
Manufacturer: BOEHRINGER ING.

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